Wales international Moriarty missed the opening game of the season through suspension, but is called up as Head Coach Bernard Jackman makes five changes to his starting line-up for the visit of the South Africans.
A new-look front row sees prop Brok Harris and hooker Elliot Dee named, as they pack down with Leon Brown.
Lock Matthew Screech is named in the second row alongside captain Cory Hill.
The final change is at fly half where Josh Lewis will make his first Guinness PRO14 start for Dragons, replacing the injured Gavin Henson. Fly half Arwel Robson is named among the replacements.
Jackman said: “The players have trained exceptionally hard all week and how we respond to last Saturday’s game with Benetton Rugby will be a good test of our character.
“We want to put our best foot forward and show we are much better than we were in the opening round.
“We’re all looking forward to seeing Ross (Moriarty) in a Dragons jersey,” he added.
“Ross has a real edge to his game and is a good leader for us already. He will give us a boost, but it's going to take a 23-man performance to make sure we get the right result.”
Dragons (v Isuzu Southern Kings): Jordan Williams, Dafydd Howells, Tyler Morgan, Jack Dixon, Hallam Amos, Josh Lewis, Rhodri Williams; Brok Harris, Elliot Dee, Leon Brown, Matthew Screech, Cory Hill (c), Aaron Wainwright, Ollie Griffiths, Ross Moriarty
Replacements: Richard Hibbard, Ryan Bevington, Lloyd Fairbrother, Brandon Nansen, Huw Taylor, Tavis Knoyle, Arwel Robson, Adam Warren
Kings: Y Penxe, M Makase, H Klassen, B Klassen, B Basson, M Banda, R van Rooyen, J Forwood, M Willemse (c), L Pupuma, S Oelofse, B De Wee, S De Wit, M Burger, A Ntsila.
Replacements: A Van Rooyen, S Ferreira, L Mguca, J-C Astle, R Lerm, G Masimla, M Du Toit, U Beyers.
Tickets for the home clash with Isuzu Southern Kings are on sale NOW!
Click HERE to buy online today or thanks to a new partnership with Leisure Trusts through the region you can also purchase tickets at the following venues:
Aneurin Leisure Trust are participating in the scheme at their venues at Ebbw Vale leisure centre, Abertillery Leisure Centre, Tredegar Leisure Centre and Parc Bryn Bach. Torfaen Leisure Trust at their venues in Cwmbran Stadium and Pontypool Active Living Centre and Caerphilly CBC at Caerphilly, Risca, Newbridge and at the Dragons training base in Ystrad Mynach Centre of Excellence.
