Fly half Sam Davies hits a double milestone as Dragons prepare to face Benetton Rugby in the United Rugby Championship (URC) at Rodney Parade on Friday night (kick-off 7:35pm).
Boss Dean Ryan makes nine changes as the Men of Gwent look to bounce back against the Italians after the European loss out in Treviso.
Wales international Ross Moriarty returns to the starting line-up for the first time since the autumn and captains the side after being released back from the national squad this week.
Moriarty is joined in the back row by flanker Ollie Griffiths, who returns following injury, and Harri Keddie, who wears the six jersey.
Prop Aki Seiuli starts at loosehead with Joe Davies and Joe Maksymiw partnering in the second row.
Adam Warren comes back into the side at centre to partner Aneurin Owen in midfield.
There will be a new-look back three at Rodney Parade with Jonah Holmes, Jordan Olowofela and full back Josh Lewis all returning.
Fly half Davies will make his 50th Dragons appearance and 150th league appearance at Rodney Parade on Friday night.
Among the replacements are Wales internationals Elliot Dee and Rhodri Williams, who both return from injury, while Fijian Mesake Doge is also back in the matchday squad.
Dragons: Josh Lewis, Jonah Holmes, Adam Warren, Aneurin Owen, Jordan Olowofela, Sam Davies, Gonzalo Bertranou; Aki Seiuli, Taylor Davies, Chris Coleman, Joe Davies, Joe Maksymiw, Harri Keddie, Ollie Griffiths, Ross Moriarty (c)
Replacements: Elliot Dee, Josh Reynolds, Mesake Doge, Huw Taylor, Dan Baker, Rhodri Williams, Jared Rosser, Ioan Davies.
